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Exogenous lipid pneumonia related to long-term use of Vicks VapoRub® by an adult patient: a case report
BMC Ear, Nose and Throat Disorders volume 16, Article number: 11 (2016)
Use of petroleum-based over the counter remedies such as Vicks VapoRub to alleviate symptoms of rhinitis is common and can be effective, but carries under-appreciated risks of adverse side effects. In this case report we highlight Exogenous Lipoid Pneumonia (ELP), an uncommon condition that results from accumulation of exogenous lipids in the alveoli, as an adverse side effect of long-term Vicks VapoRub use.
We present the case of an 85-year-old female patient with ELP apparently due to continuous application of Vicks VapoRub® to her nostrils to alleviate chronic rhinitis. She was diagnosed incidentally via chest radiograph and computed tomography (CT) scan done as follow up to finding elevated C-reactive Protein during a routine exam. The CT scan revealed a pulmonary consolidation in the lower lobe of the right lung with fat density combined with low density areas associated with focal ground-glass opacities. The patient was advised to discontinue use of petroleum-based products, and was prescribed intranasal corticosteroids for her rhinitis. Follow up 2 years later showed that the lipid consolidation had diminished in size by approximately 10 %.
Physicians must be aware that ELP can develop as a result of long-term application of petroleum-based oils and ointments to the nose and discourage such use of these products. Patients who have used petroleum-based products in this way should be screened for ELP. CT scan is the best imaging modality for establishing the diagnosis. The treatment of this condition is not well defined, but, as shown in this case, the size of the lipid mass can decrease after use of petroleum based substances is discontinued.
Exogenous lipoid pneumonia (ELP) is a rare condition resulting from the aspiration or inhalation of fat-like material of animal, vegetable or mineral origin . The frequency of ELP is difficult to establish, but autopsy series have revealed frequencies of 1 to 2.5 % . Forty four cases of ELP were identified in a nationwide retrospective study in France between 1981 and 1993 . The principal factor for ELP is the inhalation of inert, long-chain, saturated hydrocarbons found in petroleum. Mineral oils and ointments can inhibit the cough reflex and ciliary motility, thus facilitating inhalation. Their presence in the pulmonary parenchyma causes a foreign body type of inflammatory reaction [4, 5]. Most ELP cases result from the use of oil-based laxatives for the treatment of constipation, or from nasal instillation of oily products, including petroleum ointment products such as Vaseline or Vicks VapoRub® , for relief of chronic rhinopharyngeal diseases. Reported sources also include lip balm/gloss . Most of the patients who aspirate these substances are elderly people who have difficulty swallowing due to anatomic or functional issues, and who have a history of topical application or ingestion of lipid products .
Individuals with ELP can present with unspecified symptoms such as cough, dyspnoea, chest pain, haemoptysis or fever. They can also be asymptomatic, in which case ELP may be identified as an incidental abnormality on radiologic imaging [5, 8]. On physical examination findings are usually normal, although dullness on percussion, crackles, wheezes or rhonchus may be found . Laboratory findings such as leucocytosis and increased erythrocyte sedimentation rate can be found, especially when complicated by an infection. In one study increased sedimentation rate was observed in 61 % of ELP cases . Pulmonary function test results have shown a restrictive pattern in long-standing disease . Prominent radiologic abnormalities have been found in the absence of symptoms or clinical signs in many ELP cases .
High-resolution computed tomography (CT) is the best imaging modality for establishing the diagnosis of ELP. The most frequent findings are airspace consolidations, ground-glass opacities, interlobular septal thickening, airspace nodules (small poorly-defined centrilobular nodules), and mass-like lesions . The mass is typically irregular or spiculated as a result of chronic inflammation and secondary fibrosis. Since its clinical and radiological presentations are nonspecific, ELP may mimic many other diseases, including lung tumours . The presence of fat in the mass is a diagnostic feature of ELP . The radiologic manifestations of ELP can improve slowly over time, but typically remain stable even if exposure to oils or fats is discontinued. ELP-related fibrosis and destruction of normal lung architecture can result in cor-pulmonale .
Patients with rhinitis, a condition that usually presents with nasal congestion, rhinorrhea, sneezing and itching, often self-medicate, using over-the-counter decongestants or folk remedies [14, 15]. One traditional folk remedy consists of instilling medicated oil or ointment into the nose and sniffing it. A variety of oil-based products have been used, including pure sesame oil  and mentholated petroleum-based ointments such as Vicks VapoRub®.
Here we report the case of an patient in a routine medical visit with history of rhinitis and mentholated mineral ointment use who was found to have ELP.
An 85-year-old Ecuadorian female self-referred for her annual routine visit to family physician (Additional file 1: Timeline Table). She had history of recurrent allergic rhinitis events with nocturnal runny nose since childhood. She revealed daily use of the over-the-counter mentholated mineral ointment decongestant Vicks VapoRub® for approximately 50 years to ease her discomfort. She applied this product to her chest, palms and feet, and aspirated it through her nose.
The patient had no signs or symptoms of respiratory disease at the time of the visit. Her physical examination was unremarkable. Her medical history included type 2 diabetes mellitus and hypertension.
Laboratory findings demonstrated an increased CRP (31.5 mg/L, reference value 0.0 – 5.0 mg/L). After obtaining no relevant results, a follow up chest radiograph was ordered. It showed airspace consolidation as an irregular mass-like-lesion in the right lower lobe. The patient continued to be asymptomatic despite the presence of this mass. A thoracic computed tomographic (TCT) scan of the chest was ordered. This showed a pulmonary consolidation of 5.0 × 4.5 cm in the posterior basal segment of the lower lobe of the right lung, containing negative density regions measuring between −130 HU and −61 HU, indicative of intrapulmonary lipid (Fig. 1). Focal ground-glass opacities were observed in the periphery and scattered ground glass opacities bilaterally, which are suggestive of pneumonitis. We recommended that the patient stop using Vicks VapoRub®, and prescribed intranasal corticosteroids for her rhinitis.
Twenty-six months after stopping daily mentholated ointment application a follow-up TCT and CRP was ordered. The pulmonary consolidation described above was still apparent, but the bilateral scattered ground glass opacities had diminished and the size of the mass had decreased by 0.5 cm in each dimension (4.5 × 4.0 cm) (Fig. 2). CRP was in reference value (2.03 mg/L)
Although ELP is an unusual cause of chronic lung disease, it is an important consideration in the differential diagnosis of several pulmonary syndromes because progression appears to be halted, or at least slowed, by stopping exposure to the offending lipid substance. In our patient the presence of negative TCT density values in the mass implied the presence of lipid. That fact, together with follow up scan results, allowed us to rule out malignancy.
Several authors have suggested that negative density values between −150 and −30 HU in areas of consolidation are highly suggestive of intrapulmonary fat, and are consistent with ELP, especially when associated with a history of exposure to mineral oil or ointment. In order to prevent a false positive interpretation, measurements should be taken in the most hypodense part of the consolidation area, free of any aerated parenchyma on the periphery or areas of air bronchogram [5, 16, 17].
Systemic steroids have been used to slow the inflammatory response associated with ELP, but their use is supported only by few anecdotal reports [18–21]. Because inflammation will resolve spontaneously with cessation of exposure in most cases, it seems steroids can be withheld unless the lung injury is severe and progressive [8, 19].
ELP is often mild and does not appear to progress if use of the causative agent is stopped. However, there are few studies in which ELP masses are followed and measured after patients have stopped using oil-based substances. In one case involving a 38 year old woman with ELP, the mass was reported to have diminished 2 years after stopping oil ingestion, but the decrease was not quantified . In the present case we measured the ELP mass at the time of diagnosis and 26 months after the patient discontinued use of mentholated petroleum ointment, and found a 10 % decrease in size. Prospective studies should be done to determine the average rate at which ELP masses decrease after use of the causative agent is stopped.
The best treatment for ELP is prevention. However, the fact that ELP is a potential risk associated with chronic use of lipid substances is not always appreciated, even by physicians. A recent review about rhinitis in geriatric populations said that use of oil substances in the nose is generally safe and can be used adjunctively with other treatment . Mineral oil and ointment products are sold without prescription, and no information is provided for consumers or clinicians on possible hazards, especially among people at risk of aspiration, including the elderly and people with gastroesophageal reflux, dysphagia, nasal congestion or neurologic disease. Mentholated ointments have been shown to be cilio-toxic and mildly proinflammatory, increasing mucus secretion while decreasing mucus clearance . This gives the sensation of increased airflow and therefore relief of symptoms, but in fact there is no improvement in airflow or decrease in nasal resistance with the use of these products .
Health professionals need to be aware of the risks and discourage the uncontrolled use of mineral oil and ointment, especially for the very young and the elderly .
We suspect that our patient developed ELP due to excessive use of Vicks VapoRub® for chronic rhinitis. ELP was confirmed by TCT, which was ordered because of elevated CRP findings. Physicians need to be aware of this chronic adverse effect and discourage the use of mineral oil and ointment. The ability to recognize radiological manifestations of ELP can help establish an early diagnosis and start timely intervention.
The main intervention is discontinuing use of lipid substances. In the reported case, we found a 10 % decrease in size of the ELP mass 26 months after the patient stopped using Vicks VapoRub®. Further studies should be done to determine average rates at which ELP-related masses decrease after use of lipid substances is stopped.
Exogenous Lipoid Pneumonia
Thoracic Computed Tomographic
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We appreciate the guidance and support of the MECOR Program, Sonia Buist, MD and Ana Menezes, MD. We are very grateful to Javier Delgado, MD, of Interhospital, for his help with image studies in the case. We also thank Mary Chaiken, PhD, for editing this manuscript.
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CHOI, CJC, GJ assessed the patient along the time and CE made additional interviews to the patient. CHOI, CJC, GJ, CE wrote the case presentation. CD and CHA realized the discussion. All the authors reviewed the literature, made the conclusions and approved the final version of the manuscript before submission.
The authors declare that they have no competing interests.
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Cherrez Ojeda, I., Calderon, J.C., Guevara, J. et al. Exogenous lipid pneumonia related to long-term use of Vicks VapoRub® by an adult patient: a case report. BMC Ear Nose Throat Disord 16, 11 (2016). https://doi.org/10.1186/s12901-016-0032-6
- Exogenous lipoid pneumonia
- Petroleum jelly
- Case report