- Research article
- Open Access
- Open Peer Review
Surgical margins and survival after head and neck cancer surgery
- Reina Haque†1Email author,
- Richard Contreras†1,
- Michael P McNicoll†2,
- Evelyn C Eckberg†3 and
- Diana B Petitti†1
© Haque et al; licensee BioMed Central Ltd. 2006
- Received: 24 August 2005
- Accepted: 17 February 2006
- Published: 17 February 2006
Mixed results exist as to whether positive surgical margins impact survival. The aim of this study was to determine whether positive surgical margins are indeed associated with decreased survival in patients with primary head and neck cancer.
We conducted a retrospective cohort study of 261 cases diagnosed with cancer of the larynx or tongue between 1995 and 1999. Cases were followed through December 31, 2002. Survival curves by margin status were generated by Kaplan-Meier methods. Categorical data were evaluated with odds ratios (OR).
All-cause mortality was markedly higher in cases with positive margins as compared with those with negative margins (54% versus 29%, P = 0.005). This pattern also appeared after adjusting for age and sex (OR = 2.97, 95% CI: 1.29 – 6.84).
Our findings suggest that positive surgical margin status is associated with increased mortality. This association also generally persists after adjustment for tumor size, stage, and adjuvant therapy.
- Neck Cancer
- Positive Margin
- Margin Status
- Negative Margin
- Tongue Cancer
Approximately 37,000 men and women in the U.S. were diagnosed with head and neck cancers in 2003 . In particular, individuals with tongue and larynx cancer accounted for 45% of the head and neck cancer cases diagnosed. Such cancers are more frequently diagnosed among men and in people over age 50. These cancers are highly fatal, and mortality rates have not decreased significantly over time . Based on recent national U.S. statistics, the five-year survival is 64% for larynx cancer and 56% for cancer of the oral cavity [1, 2]. The treatment plan for an individual patient depends on a number of factors, including the exact location of the tumor, the stage of the cancer, and the person's age and general health status . Patients with head and neck cancer are frequently treated with surgery, with removal of the cancer including some of the healthy tissue around it. Surgery may be followed by radiation treatment. But, the side effects of aggressive surgery and radiation can be devastating. Severe consequences may include permanent loss of voice, swallowing and speech problems, tongue and neck deformity and scar, and paralysis of cranial nerves. Significant expertise is needed to preserve healthy tissue to the extent possible to maintain these important functions while ensuring that the cancer is removed.
Although obtaining negative surgical margins (i.e., cancer was entirely removed) is the goal of the head and neck surgeon, achieving this may be impossible because of functional consequences. Thus, some patients are left with positive surgical margins (i.e., those in which residual cancer cells remain) to preserve vital organs like the carotid artery. Whether positive surgical margins impact survival remains equivocal . Positive surgical margins are reported to be negatively associated with survival in many, although not in all of the published studies [5, 6]. Some studies did not find an association between positive surgical margins and an increased risk of mortality; however, many of these studies included a small number of patients, or the possibility existed that there was no increase in mortality because patients with positive surgical margins received adjuvant radiation therapy [7, 8]. In addition, many of the prior studies did not attempt to exclude cases with a known history of cancer, which may impact survival. The objective of this study was to determine whether positive surgical margins are indeed associated with lower survival.
Design and setting
The study was a retrospective cohort of larynx and tongue cancer cases diagnosed at Kaiser Permanente Southern California (KPSC), a health maintenance organization of 11 medical centers with over three million members. The study was reviewed and approved by the KPSC Institutional Review Board.
Study patients were identified through the health plan's cancer registry. The KPSC cancer registry is a population-based registry that reports to the American College of Surgeons' National Cancer Data Base and National Cancer Institute's Surveillance Epidemiology and End Results Program. Primary tongue and larynx cancer cases included patients who were diagnosed between January 1, 1995 and December 31, 1999 who underwent surgical resection as the primary course of treatment, and were active health plan members of KPSC on the date of surgery (International Classification of Disease for Oncology [ICD-O] Version 2 codes C01.9, C02.0–C02.4, C02.8, C02.9, C32.0–C32.3, C32.8, C32.9). To minimize the possibility of having biased survival times, we excluded patients with a known history of cancer.
Cases with negative margins included patients with no involvement of margins (i.e., reported free by the pathologist). Cases with positive margins were defined to be those in whom residual cancer cells were found in the surgical margin when tissue sections were examined with a microscope (microscopically positive) or visible to the unaided eye (grossly positive). These categories describe the surgical margins status after resection of the primary tumor as recorded by the pathologist.
Variables abstracted from the cancer registry included age at diagnosis, sex, ethnicity, ICD-O (International Classification of Diseases, Oncology) diagnosis, diagnosis date, TNM stage (tumor, node, metastases), surgery date, surgical margin status, radiation therapy, vital status, and cause of death.
Vital status was ascertained by using a combination of research and automated databases. Deaths were identified through the California's master file of death certificates, inpatient hospital files, the cancer registry, and the National Death Index. Because cause of death information was missing for over 90% of the patients in these automated databases, we used all-cause mortality as the endpoint.
We classified patients as being alive at end of study if they had any one of the following after December 31, 2002: 1) an outpatient doctor visit; 2) an inpatient hospitalization; or 3) received a pharmacy prescription. Because these patients have a highly fatal cancer requiring medical care, they would appear in one of these databases.
The statistical significance of differences for categorical data was evaluated using chi-square or Fisher's exact test. Odds ratios (OR) were used to estimate the size of associations; ORs were adjusted for age and sex, and stratified by tumor characteristics and surgical treatment separately. For the survival analysis, patients were followed from the date of surgery to December 31, 2002. We examined overall survival defined as the interval between the date of surgery and December 31, 2002 or the date of death due to any cause, whichever occurred first. Survival time was censored if a patient lived past the end of follow-up. Survival curves by margin status were generated by Kaplan-Meier methods. Differences in survival between cases with positive and negative margins were evaluated using the log-rank test. All analyses were conducted with SAS Version 8 .
Demographic characteristics of incident tongue and larynx cancer cases
N (N = 261)
Year of diagnoses
Age at diagnosis
Tumor characteristics by margin status in incident tongue and larynx cancer cases
Negative Margins (N = 233)
Positive Margins (N = 28)
Tumor size (cm)
0 – I
Tumor size (cm)
0 – I
Tumor size (cm)
0 – I
Association between surgical margins and mortality by tumor characteristics
Odds Ratio (95% CI)
Age-sex adjusted OR (95% CI)
≤ 2 cm
0.45 (0.05 – 3.89)
0.41 (0.04 – 4.05)
> 2 cm
2.47 (0.69 – 8.91)
2.37 (0.58 – 9.75)
0 – III
3.32 (0.92 – 11.99)
3.34 (0.86 – 13.07)
1.07 (0.35 – 3.29)
0.95 (0.26 – 3.51)
Association between surgical margins and mortality by surgical treatment in cases with tongue or larynx cancer
Odds Ratio (95% CI)
Age-sex adjusted OR (95% CI)
2.85 (1.19 – 6.89)
2.97 (1.29 – 6.84)
2.38 (0.33 – 14.85)
2.20 (0.42 – 11.55)
Surgery + adjuvant radiotherapy
2.23 (0.77 – 6.74)
1.98 (0.68 – 5.84)
Cause of death was not available in the various electronic files. We found cause of death for only 25 individuals. Of these 25 patients, 15 (60%) died from a malignant neoplasm of the head or neck; 5 (20%) due to cardiovascular disease; and 5 (20%) died due to pneumonia or other causes.
We examined the association between surgical margin status and survival using a cohort of 261 patients diagnosed from 1995 to 1999, with some patients followed five or more years. All-cause mortality was markedly higher in cases with positive margins as compared with those with negative margins (54% versus 29%) during the eight year study period. The age and sex adjusted OR suggests that positive surgical margin status is associated with nearly a three-fold increased risk of mortality (2.97, 95% CI: 1.29 – 6.84). This association appears to generally persist even after adjustment type of treatment (surgery alone or with adjuvant radiation therapy), among cases with large tumors (>2 cm), and those with TNM stage 0 to III disease at diagnosis; however, these analyses were based on small numbers of cases. These findings are consistent with the few reports that specifically examined the effect of surgical margins on survival of head and neck cancer [4, 5, 10, 11]. Other studies did not find a clear association between positive surgical margins and an increased risk of death, possibly due to even smaller sample sizes to detect a difference (e.g. ), or did not specifically examine the effect of margins on survival.
Use of all-cause mortality is a potential limitation. We examined all cause mortality because cause of death information was available for only 25 cases who died. Using all-cause mortality would underestimate mortality due to cancer, but it is unlikely to lead to bias in estimation of the relationship of margins with survival since death due to causes other than cancer is unlikely to be related to margin status. In addition, we did not have information on chemotherapy in patients who might have experienced subsequent metastases. Indication for adjuvant therapy such as chemotherapy and radiotherapy would have entailed patient chart review which was beyond the scope of this study. Another potential limitation is was the lack of electronic data on the sub-anatomic sites of the tongue to examine the association between margin status and mortality. For example, it is more complicated to obtain negative margins for the base of tongue tumors. Although the present study includes one of the largest series investigated, the study only included 28 patients with positive surgical margins. Therefore, in the analyses we examined overall survival for the two primary sites combined that would be based on more stable estimates.
A major strength of the study is that it includes a large population-based cohort, which is more likely to be representative of all individuals who develop cancer of tongue and larynx than studies from academic specialty centers. Virtually all previous studies we identified were based on patients from academic specialty centers who might have been more likely to have more aggressive forms of the disease [4–12]. Another strength is that our study involved patients who were diagnosed over a five-year time frame, during which surgical and treatment modalities were unlikely to vary substantially. Some previous studies included patients who diagnosed over decades. Further, our study excluded patients with a known history of cancer. All patients receive all their health care within this integrated HMO; therefore, the study included virtually every case diagnosed and treated during the study period.
Cancers of larynx and tongue are aggressive and prognosis is poor. Surgery has been the primary course of treatment for these diseases. Our results suggest that positive surgical margin status is associated with decreased survival. However, achieving negative margins can cause impairment in important functions such as chewing, swallowing and speech, and adversely affect quality of life. Measures of quality of life are not available in the health plans electronic databases, and ascertaining such information was beyond the scope of the present study. Detailed prospective data collection would be needed to understand the functional limitations experienced by patients with negative and positive margins. The appropriate balance between quality and quantity of life remains a difficult clinical decision.
This study was supported by the KPSC Department of Research & Evaluation. The authors have no potential conflict of interest. The authors thank Gerri Salazar for her assistance in abstracting cancer registry data.
- American Cancer Society: Cancer facts and figures. 2003, [http://www.cancer.org]Google Scholar
- National Cancer Institute: Surveillance, Epidemiology, End Results. [http://seer.cancer.gov/publications/raterisk/ratestoc.html]
- Ribeiro KC, Kowalski LP, Latorre MR: Impact of comorbidity, symptoms, and patients' characteristics on the prognosis of oral carcinomas. Arch Otolaryngol Head Neck Surg. 2000, 126: 1079-1085.View ArticlePubMedGoogle Scholar
- Sessions DG, Spector GJ, Lenox J, Haughey B, Chao C, Marks J: Analysis of treatment results for floor-of-mouth cancer. Laryngoscope. 2000, 110: 1764-1772. 10.1097/00005537-200010000-00038.View ArticlePubMedGoogle Scholar
- Affleck DG, Karwande SV, Bull DA, Haller JA, Stringham JC, Davis RK: Functional outcome and survival after pharyngolaryngoesophagectomy for cancer. Am J Surg. 2000, 180: 546-550. 10.1016/S0002-9610(00)00517-1.View ArticlePubMedGoogle Scholar
- De Vicente JC, Recio OR, Penda SL: Oral squamos carcinoma of the mandibular region: A survival study. Head Neck. 2001, 23: 536-543. 10.1002/hed.1075.View ArticlePubMedGoogle Scholar
- Klotch DW, Muro-Cacho C, Gal TJ: Factors affecting survival for floor-of-mouth carcinoma. Otolaryngol Head Neck Surg. 2000, 122: 495-498. 10.1016/S0194-5998(00)70090-8.PubMedGoogle Scholar
- Loree TR, North JH, Werness BA, Nangia R, Mullins AP, Hicks WL: Malignant peripheral nerve sheath tumors of the head and neck: analysis of prognostic factors. Otolaryngol Head Neck Surg. 2000, 122: 667-672. 10.1016/S0194-5998(00)70193-8.PubMedGoogle Scholar
- SAS Institute Inc, Version 8. 1999, Cary, NC: SAS Institute IncGoogle Scholar
- Patel SG, Meyers P, Huvos AG, Wolden S, Singh B, Shaha AR, Boyle JO, Pfister D, Shah J, Kraus DH: Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer. 2002, 95: 1495-1503. 10.1002/cncr.10849.View ArticlePubMedGoogle Scholar
- Smeele LE, Leemans CR, Langendijk JA, Tiwari R, Slotman BJ, Van der Waal I, Snow G: Positive surgical margins in neck dissection specimens in patients with head and neck squamous cell carcinoma and the effect of radiotherapy. Head Neck. 2000, 22: 559-563. 10.1002/1097-0347(200009)22:6<559::AID-HED3>3.0.CO;2-7.View ArticlePubMedGoogle Scholar
- Gillenwater AM, Hessel AC, Morrison WH, Burgess MA, Silva EG, Roberts D, Goepfert H: Merkel cell carcinoma of the head and neck: effects of surgical excision and radiation on recurrence and survival. Arch Otolaryngol Head Neck Surg. 2001, 127: 149-154.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6815/6/2/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.