Skip to main content

Nasopharyngeal leiomyomatous hamartoma: case report

Abstract

Background

Fibroma, neurofibroma, and papilloma are the most commonly encountered benign lesions in the nasopharynx. Hamartomas are non-neoplastic overgrowth of mature/differentiated tissue indigenous to the specific part of the body in which they develop. Most hamartomas are located in the liver, spleen, lungs, and pancreas. However, nasopharyngeal hamartoma is rare.

Case presentation

We describe here a 77-year-old Japanese woman who presented with a mass arising from the left lateral wall of the nasopharynx. Computed tomography (CT) revealed a soft tissue mass without bony erosion, suggesting that the mass was a benign tumor such as a fibroma. Pathological examination showed that the mass was a leiomyomatous hamartoma.

Conclusion

To our knowledge, this is the first report of a leiomyomatous hamartoma in the nasopharynx. Although leiomyomatous hamartoma in the nasopharynx is extremely rare, it should be kept in mind during differential diagnosis.

Peer Review reports

Background

Hamartomas are non-neoplastic overgrowth of mature/differentiated tissue indigenous to the specific part of the body in which they develop[1]. Most hamartomas are located in the liver[2], spleen[3], lungs[4], and pancreas[5], although several hamartomas in the nasopharynx have been reported[1, 6, 7]. Hamartomas are classified as epithelial, mesenchymal, or mixed epithelial and mesenchymal types. Respiratory epithelial adenomatoid hamartoma, a subtype of epithelial hamartoma, is the most common type of hamartoma in the nasal cavity or nasopharynx; the clinicopathological features of 31 such patients have been described[8]. Mesenchymal hamartomas are much rarer than epithelial type hamartomas. Mesenchymal hamartomas can be subclassified as chondroid, chondromesenchymal, angiomatous, lipomatous, and leiomyomatous hamartomas, depending on their major tissue type[7]. We describe here a patient with a nasopharyngeal leiomyomatous hamartoma.

Case presentation

A 77-year-old Japanese woman with no significant previous medical history presented at our hospital for a cheek swelling sensation during the previous week. Her general condition was very good, without fever or pain, and her cheek was not swollen. Nasal fiberscopic analysis revealed a small mass at the left wall of the nasopharynx. Its smooth surface suggested a benign lesion. Computed tomography (CT) without contrast enhancement showed a mass almost 5 mm in diameter at the left wall of the nasopharynx (Figure 1). The mass was excised by trans-nasal endoscopic surgery under general anesthesia (Figure 2). Pathologic examination showed cells with the mature phenotype of smooth muscle, but arranged haphazardly (Figure 3). Immunohistochemical labeling was performed using an antibody against smooth muscle actin (DAKO, Carpinteria, CA; dilution 1:50), S-100 protein (DAKO, dilution 1:200) and desmin (DAKO, dilution 1:200). Immunoreaction were clearly positive in smooth muscle cells fascicles (Figure 4A and B) (positive immunoreactions for smooth muscle actin and desmin) and nervous tissue (Figure 4C) (positive immunoreaction for S-100). Finally, the patient was diagnosed with a nasopharyngeal leiomyomatous hamartoma. To date, almost 2 years after surgery, there has been no evidence of recurrence, and her mucosa remains healthy.

Figure 1
figure1

Axial CT images, revealing a small mass almost 5 mm in diameter at the left wall of the nasopharynx.

Figure 2
figure2

Gross examination of the excised specimen, showing an oval lesion with smooth surface.

Figure 3
figure3

Pathological features of the specimen, showing interlacing bundles of smooth muscles (Hematoxylin and Eosin; 400x).

Figure 4
figure4

The histopathological study of leiomyomatous hamartoma in immune-histochemical stain (bar; 100 μm). A: Positive reaction with smooth muscle actin in the muscle bundles. B: Positive reaction with desmin in the muscle bundles (arrow), but negative in the nerve. C: Positive reaction with S-100 protein in the nerve (arrow), but negative in smooth muscle bundles.

Conclusions

Hamartomas are non-neoplastic overgrowth of mature/differentiated tissue indigenous to the specific part of the body in which they develop[1]. Most hamartomas are located in the liver[2], spleen[3], lungs[4], and pancreas[5], but some have been reported in the nasopharynx[1, 6, 7]. Hamartomas are classified as epithelial, mesenchymal, and mixed epithelial and mesenchymal types. Respiratory epithelial adenomatoid hamartomas are the most common subtype in the nasal cavity or nasopharynx[8]. Mesenchymal hamartomas, which are much less common than epithelial hamartomas, can be subdivided into chondroid, chondromesenchymal, angiomatous, lipomatous, and leiomyomatous hamartomas, depending on the preponderant tissue[7]. Although several leiomyomatous hamartomas have been observed in the oral cavity[9, 10], none to date has been reported in the nasopharynx. To our knowledge, this may be the first report of a nasopharyngeal leiomyomatous hamartoma.

Immunohistochemical characteristics are essential in differentiating leiomyoma. The smooth muscle actin and S-100 protein are the most commonly used markers in confirming the histomorphologic findings in leiomyomatous hamartoma[10]. However, use of desmin has been reported[11], because expression of smooth muscle actin is not specific for smooth muscle cells, but is also expressed by myofibroblasts. The S-100 protein is normally present in cells derived from the neural crest, chondrocytes, adipocytes, myoepithelial cells, macrophages, and keratinocytes. Adipose tissue and nerve fibers may also have positive staining but smooth muscle have negative staining. So, S-100 protein can be a key immunohistochemical marker to differentiate leiomyomatous hamartoma from leiomyoma.

The pathogenesis of nasopharyngeal leiomyomatous hamartoma is not clear. Leiomyomatous hamartomas in the oral cavity tend to occur in the midline of the maxillary gingiva and tongue[9, 10]. This may have been due to an embryogenic error occurring during the fusion of the primary palate with the lateral palatine processes during the formation of the palate[11]. The mass in our patient was located in the left lateral wall of the nasopharynx, suggesting that it may have arisen from smooth-muscle cells in the left wall of the nasopharynx, caused by unknown origin, rather than through embryogenic error. In summary, we have described a patient with a nasopharyngeal leiomyomatous hamartoma. To our knowledge, this may be the first report of a leiomyomatous hamartoma in the nasopharynx.

Consent

Written informed consent was obtained from the patient for publication of this Case report and any accompanying images.

Abbreviations

CT:

Computed tomography.

References

  1. 1.

    Owens D, Alderson D, Garrido C: Nasopharyngeal hamartoma: importance of routine complete nasal examination. J Laryngol Otol. 2004, 118: 558-560.

    Article  PubMed  Google Scholar 

  2. 2.

    Rosado E, Cabral P, Campo M, Tavares A: Mesenchymal hamartoma of the liver - a case report and literature review. J Radiol Case Rep. 2013, 7: 35-43.

    PubMed  PubMed Central  Google Scholar 

  3. 3.

    Basso SM, Sulfaro S, Marzano B, Fanti G, Chiara GB, Lumachi F: Incidentally discovered asymptomatic splenic hamartoma with rapidly expansive growth: a case report. In Vivo. 2012, 26: 1049-1052.

    PubMed  Google Scholar 

  4. 4.

    Umashankar T, Devadas AK, Ravichandra G, Yaranal PJ: Pulmonary hamartoma: Cytological study of a case and literature review. J Cytol. 2012, 29: 261-263.

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. 5.

    Kawakami F, Shimizu M, Yamaguchi H, Hara S, Matsumoto I, Ku Y, Itoh T: Multiple solid pancreatic hamartomas: a case report and review of the literature. World J Gastrointest Oncol. 2012, 4: 202-206.

    Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Metselaar RM, Stel HV, van der Baan S: Respiratory epithelial adenomatoid hamartoma in the nasopharynx. J Laryngol Otol. 2005, 119: 476-478.

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Park SK, Jung H, Yang YI: Mesenchymal hamartoma in nasopharynx: a case report. Auris Nasus Larynx. 2008, 35: 437-439.

    Article  PubMed  Google Scholar 

  8. 8.

    Wenig BM, Heffner DK: Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases. Ann Otol Rhinol Laryngol. 1995, 104: 639-645.

    CAS  Article  PubMed  Google Scholar 

  9. 9.

    Yoshihara T, Oda A, Takahashi Y, Ishii T, Yaku Y: Fibrous hamartoma of the tongue: report of a case with immunohistochemical and ultrastructural studies. Int J Pediatr Otorhinolaryngol. 1995, 33: 171-178.

    CAS  Article  PubMed  Google Scholar 

  10. 10.

    Nava-Villalba M, Ocampo-Acosta F, Seamanduras-Pacheco A, Aldape-Barrios BC: Leiomyomatous hamartoma: report of two cases and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008, 105: e39-e45.

    Article  PubMed  Google Scholar 

  11. 11.

    Zaitoun H, Triantfyllou A: Smooth muscle hamartoma of the hard palate. J Oral Pathol Med. 2007, 36: 245-249.

    CAS  Article  PubMed  Google Scholar 

Pre-publication history

  1. The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6815/14/5/prepub

Download references

Acknowledgements

We are most grateful to the patient in this case report, for her reliance on our medical work and consent to be able to publish this case. Furthermore, we thank Dr. Koichi Honma (Dokkyo University, Japan) for pathological data.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Yuh Baba.

Additional information

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

The author YB has made the study design and concept, drafted the manuscript, and made critical review. TN has obtained the data and figures, and drafted the manuscript and references. YK has made a critical review for the manuscript and added comments to discussion. All authors read and approved the final manuscript.

Authors’ original submitted files for images

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Nishiyama, T., Kato, Y. & Baba, Y. Nasopharyngeal leiomyomatous hamartoma: case report. BMC Ear Nose Throat Disord 14, 5 (2014). https://doi.org/10.1186/1472-6815-14-5

Download citation

Keywords

  • Hamartoma
  • Nasopharynx
  • Otolaryngologic tumor