Fig. 1From: Frequency of mitochondrial m.1555A > G mutation in Syrian patients with non-syndromic hearing impairment(a): PCR-RFLP analysis of the only Syrian family found with m.1555A > G mutation: a 248 bp PCR fragment is digested with BsmAI. DNA ladder (the first panel). The wild-type mtDNA is cleaved in to tow fragments, 192 and 56 bp in length (the last panel). PCR product containing the m.1555A > G mutation is not cleaved (the other left panels). (b): Partial Sequence chromatograms from a normal hearing individual (down) and affected proband with the m.1555A > G mutation in the mitochondrial 12S rRNA gene (top) with the forward and reverse primers. The small arrows indicate the localization of the change of an Adenine to Guanine nucleotide at position 1555 of the 12S rRNA geneBack to article page