Skip to main content

Table 1 Audiometry findings, present regimen and length of aminoglycoside use in group I(n = 7) and II (n = 4) patients showing audiological evidence of hearing loss

From: Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up

Sr. No. (Group) Length of treatment (Days) Present regimen (Drugs) PTA0 PTA2 PTA4 PTA6 PTA8 PTA10 PTAc
1 (I) 180 A, F, E, P, Py N N N HFL HFL HFL HFL
2 (I) 60 A, F, E, P, Py N HFL HFL HFL FLAT FLAT FLAT
3 (I) 180 A, F, E, P, Py N N N HFL HFL HFL HFL
4 (I) 180 A, F, E, P, Py N N N HFL HFL FLAT FLAT
5 (I) 180 A, F, E, P, Py N N N HFL HFL HFL HFL
6 (I) 180 A, F, E, P, Py N N N HFL HFL HFL HFL
7 (I) 180 A, F, E, P, Py N N N HFL HFL HFL HFL
8 (II) 120 K, F, E, P, Py N N N HFL FLAT FLAT FLAT
9 (II) 180 K, F, E, P, Py N N N HFL HFL HFL HFL
10 (II) 180 K, F, E, P, Py N N N HFL HFL FLAT FLAT
11 (II) 180 K, F, E, P, Py N N N HFL HFL HFL HFL
  1. A = amikacin, F = flouroquinolone, E = ethionamide, P = Para-amino salicylic acid, Py = Pyrazinamide, K = kanamycin, Days = days of aminoglycoside use in present regimen, PTA0 = baseline pure tone audiogram, PTA2 = pure tone audiogram after 2 months of aminoglycoside use, PTA4 = pure tone audiogram after 4 months of aminoglycoside use, PTA6 = pure tone audiogram after 6 months of aminoglycoside use, PTA8 = pure tone audiogram after 8 months of aminoglycoside use, PTA10 = pure tone audiogram after 10 months of aminoglycoside use, PTAc = pure tone audiogram after completion of therapy for MDR-TB, N = Normal, HFL = High frequency loss (hearing loss involving frequencies of 4000, 6000 and 8000 Hz), FLAT = Hearing loss involving frequencies in range of 250–3000 Hz along with involvement of 4000, 6000 and 8000 Hz (Criteria for hearing loss as defined in methods section).