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Table 1 Audiometry findings, present regimen and length of aminoglycoside use in group I(n = 7) and II (n = 4) patients showing audiological evidence of hearing loss

From: Audiologic monitoring of multi-drug resistant tuberculosis patients on aminoglycoside treatment with long term follow-up

Sr. No. (Group)

Length of treatment (Days)

Present regimen (Drugs)

PTA0

PTA2

PTA4

PTA6

PTA8

PTA10

PTAc

1 (I)

180

A, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

2 (I)

60

A, F, E, P, Py

N

HFL

HFL

HFL

FLAT

FLAT

FLAT

3 (I)

180

A, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

4 (I)

180

A, F, E, P, Py

N

N

N

HFL

HFL

FLAT

FLAT

5 (I)

180

A, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

6 (I)

180

A, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

7 (I)

180

A, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

8 (II)

120

K, F, E, P, Py

N

N

N

HFL

FLAT

FLAT

FLAT

9 (II)

180

K, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

10 (II)

180

K, F, E, P, Py

N

N

N

HFL

HFL

FLAT

FLAT

11 (II)

180

K, F, E, P, Py

N

N

N

HFL

HFL

HFL

HFL

  1. A = amikacin, F = flouroquinolone, E = ethionamide, P = Para-amino salicylic acid, Py = Pyrazinamide, K = kanamycin, Days = days of aminoglycoside use in present regimen, PTA0 = baseline pure tone audiogram, PTA2 = pure tone audiogram after 2 months of aminoglycoside use, PTA4 = pure tone audiogram after 4 months of aminoglycoside use, PTA6 = pure tone audiogram after 6 months of aminoglycoside use, PTA8 = pure tone audiogram after 8 months of aminoglycoside use, PTA10 = pure tone audiogram after 10 months of aminoglycoside use, PTAc = pure tone audiogram after completion of therapy for MDR-TB, N = Normal, HFL = High frequency loss (hearing loss involving frequencies of 4000, 6000 and 8000 Hz), FLAT = Hearing loss involving frequencies in range of 250–3000 Hz along with involvement of 4000, 6000 and 8000 Hz (Criteria for hearing loss as defined in methods section).