Obliteration of radical cavities with autogenous cortical bone; long-term results
© Abdel-Rahman et al; licensee BioMed Central Ltd. 2008
Received: 31 January 2008
Accepted: 29 July 2008
Published: 29 July 2008
To evaluate the long-term surgical outcome(s) in patients who have undergone canal-wall-down operation with mastoid and epitympanic obliteration using autologous cortical bone chips, bone pate and meatally-based musculoperiosteal flap technique.
Retrospective evaluation of seventy patients operated during 1986–1991 due to a cholesteatoma. An otomicroscopy was performed to evaluate the postoperative outer ear canal configuration with a modified Likert scale (1 – 4). The outer ear canal physical volume was assessed by tympanometry. The hearing outcome and a patient-filled questionnaire were also analyzed.
The posterior wall results were 1.8 (± 0.9 SD) and the attic region 1.8 (± 0.9 SD) (ns., p > 0.05). These values show either no cavity formation or minor formation of a cavity, with a good functional result. The mean volume of the operated ear canal was 1.7 (± 0.5 SD) ml. The volume of the contralateral ear canal was 1.2 (± 0.3 SD) ml (*** p < 0.0001). A comparison of the current mean ABG to the preoperative mean ABG and to the ABG at one-year postoperatively, 5-years postoperatively or 10-years postoperatively showed no statistical significance (p > 0.05).
ABG does not significantly change in the long-term. The configuration of the cavity tends to change, however, the obliteration material is stable in the long-term and clinically significant cavitation rarely occurs.
Canal-wall-down (CWD) tympanomastoidectomy is a well established method in surgery due to cholesteatoma . It provides a good intraoperative exposure and an easy postoperative monitoring. The size of the surgical cavity can be diminished with obliteration to create a small cavity that is self-cleaning and easily maintained . Several authors have demonstrated the usefulness of mastoid obliteration technique and considered it a safe method to diminish a surgical cavity in CWD surgery [3–7]. However, there are only a few studies that have evaluated the configuration of the cavity and the durability of the obliteration material itself in the long-term [6, 8–10].
CWD surgery creates a large open cavity, with several possible problems . Both autologous and synthetic materials have been used for obliteration [3, 12–14]. In our clinic, autologous cortical bone chips and pate, a meatally based musculoperiosteal flap ("Palva flap"), and temporal fascia are mainly used. The CWD tympanomastoidectomy with this obliteration method has been well characterized [15, 16].
We have studied the long term condition of ears that underwent CWD mastoidectomy with mastoid and epitympanic obliteration using autogenous bone chips, bone pate and a musculoperiosteal flap. All the patients that participated in the study were followed at least for 15 years. Clinical experience suggests that the configuration of the cavity changes during the long-term follow-up. Parts of the cavities tend to enlarge and cavities that are difficult to treat occur . We have measured the volumes of the reconstructed ear canals, and evaluated the configuration of a possible cavity and problems caused by that.
Between the years 1986 – 1991, a series of 133 CWD tympanomastoidectomies, due to a cholesteatoma, were performed. A musculoperiosteal flap ("Palva flap") was used with autogenous bone for obliteration and reconstruction, by experienced otosurgeons at the Department of Otorhinolaryngology, University of Helsinki. The autogenous cortical bone chips (approximate size 0.5 – 1 cm2), and cortical bone pate were taken from the temporal bone, above the mastoid. The mastoid cavity and epitympanum were filled with these bone chips and bone pate. The obliterated cavity was lined with a piece of temporal fascia and with the musculoperiosteal flap. The flap was not fixed. The ossicular chain was reconstructed either during the analyzed CWD surgery with obliteration or in a later tympanoplasty with autologous ossicular bone or autologous cortical bone. Meatoplasty was not performed routinely. The ear was packed and at the one week follow-up, the packing was removed.
All these patients were invited to the study and were sent an informed consent. Of the 94 patients willing to participate, 70 took part in the study. The patient data, operative details and audiological evaluations were collected retrospectively and analyzed.
The design of this study was proved by the local ethical committee at the Department of Otorhinolaryngology, University of Helsinki. All these patients gave their written informed consent to participate in the study.
Otological and audiological examination
An otomicroscopy and a tympanometry were performed. In addition, the diameter of the entrance of the outer ear canal was measured with the aid of an ear speculum (6 mm, 8 mm, 10 mm or more). The formation of the cavity in the outer ear canal and in the attic region was evaluated with a modified Likert scale (1 = no cavity formation; 2 = minor formation of a cavity, with a good functional result; 3 = moderate cavity formation, crusting; 4 = major cavity formation, crusting, cholesteatomatic growth in the cavity) by four otosurgeons. Pure-tone audiometry thresholds (0.5, 1, 2 and 4 kHz PTA) via air- (AC) and bone-conduction (BC) were determined and the air-bone gap (ABG) was calculated. The patients filled in a questionnaire and the data of the questionnaires were analyzed with PrismStat (GraphPad Software Inc., San Diego, USA) (Appendix 1). In the questionnaire the patients were asked the frequency of mastoid debridements and whether the ear had been dry or had it discharged since the surgery. Also problems with the use of hearing aids were evaluated. The t-test was used for statistical analysis (* p < 0.05).
In our study there was a male preponderance, 48 males versus 22 females participated. The mean age of the patients at the operation was 40 (± 13 SD) years (range from 7 to 66 years) and at the time of evaluation was 59 (± 13 SD) years (median 60 years) with a mean follow-up period 18 (± 1.5 SD) years (median 18 years).
Operations to the studied ear prior the evaluated CWD surgery
Type of surgery
Number of surgeries
CWD operation, without obliteration
Operations to the studied ear after the evaluated CWD surgery
Type of surgery
Number of surgeries
Otomicroscopy and volume of the cavity
Posterior wall and attic reconstruction
1.8 ± 0.9 (posterior wall)
1.8 ± 0.9 (attic)
Mean AC (air conduction), BC (bone conduction) and ABG (air-bone gap) values of the patients during the follow-up
47 ± 5
47 ± 9
45 ± 8
45 ± 7
59 ± 9
21 ± 7
21 ± 8
24 ± 7
20 ± 5
31 ± 9
27 ± 7
25 ± 6
22 ± 5
25 ± 7
26 ± 7
Patients air-bone gaps during the follow-up
Air-bone gap (dB)
> 30 (poor)
Twenty-nine patients (40%) were hearing aid users. Twenty-two of these (76%) were using a hearing aid in the operated side or in both sides. Sixteen of these patients (73%) were comfortable using the hearing aid in the operated ear. On the other hand, five patients had recurrent problems and four patients were unable to wear the aid in the operated ear. Typical problems which these patients were encountering: recurrent infection of the cavity due to hearing aid use (7 patients), fitting problems (5 patients), poor hearing level (6 patients) or combination of these.
A total of 133 patients underwent CWD surgery with complete epitympanic and mastoid obliteration 18 (± 1.5 SD) years ago at our department. Of these, 94 patients were willing to participate and 70 (53%) took part in the study. The data of patients that gave their written informed consent but did not actually participate, were not included. Dense cortical bone chips, collected from the mastoid bone, and cortical bone pate were used for the obliteration of the surgical cavity. A meatally based musculoperiosteal flap was raised when CWD surgery was anticipated.
We were especially interested in the stability of the obliteration material that was used. The musculoperiosteal flap atrophies postoperatively, but it often leaves a smooth lining for the cavity . Reconstructed canal walls and reconstructed epitympanic cavities tend to enlarge postoperatively . Sometimes these pockets are deep and may cause cholesteatomatic growth in the cavity.
Our results show that the mastoid obliteration with autogenous cortical bone, mainly cortical bone chips, is an efficient and long lasting way to diminish the surgical cavity. Most of the cavities were small and predominantly trouble free. The meatally based musculoperiostel flap will provide a smooth surface for the cavity and deep pockets with cholesteatomatic growth are rare. We observed no significant difference in the resorption of bone from the epitympanic area compared to the mastoid area.
No meatoplasty was routinely done to our patients during the analyzed CWD surgery with obliteration. However, in six cases meatoplasty was performed. During the follow-up, meatoplasty was done to nine patients. Twenty patients were operated earlier and some of them in other hospitals. It is possible that some of these patients had meatoplasty, which was not mentioned in our patient records. To our knowledge, at least 15 patients (21%) had a meatoplasty. During the last follow-up visit, it was possible to do an otomicroscopy to all of the patients and reliably evaluate the ear canal and tympanic membrane.
The acoustic properties of an obliterated cavity are considered to be better than an open cavity [18–21]. It is possible that new bone formation facilitated by a periosteal flap in the CWD cavity may provide acoustic properties similar to those of the normal ear canal [18, 22, 23]. Our results with hearing were acceptable, showing that in CWD surgery, the tympanoplasty does save the hearing even in the long run. The differences between the preoperative, 1-year, 5-year, 10-year and current ABGs were not statistically significant. 25 patients (36%) showed good or excellent gap closure after a mean follow-up period of 18 ± 1.5 years. This can be considered as a good result.
Twenty-nine patients (40%) were hearing aid users. In most cases the aid was fitted into the operated ear. Those patients felt comfortable using the hearing aid in the operated ear. The benefit of using a hearing aid among our patients seems to be the same as with elderly unoperated patients [24, 25]. Also the problems our patients encountered were of same kind as compared to elderly unoperated hearing aid users [24, 25].
A 7-year follow-up of the reconstructed ear canals showed that the ear canal has a tendency to enlarge due to the atrophy of the musculoperiosteal flap [15, 16]. Our results show that the difference of the volume between the operated and unoperated ears is significant. However, clinically this difference is still quite unsignificant due to the fact that most of the cavities were self-cleaning and did not contain significant retractions.
Epidermoid cells that are not removed at the initial operation can regrow and cause a residual cholesteatoma . Even beyond 6 years follow-up residual cholesteatomas are still observed . No residual cholesteatomas were seen in our material during a mean follow-up period of 18 ± 1.5 years. No cholesteatomas were found or operated that would have been located among the obliteration material. The autogenous material was always taken before the actual surgery.
Formation of new retraction pockets to the cavity can retain keratin and develop into a new disease as a recurrent cholesteatoma. Six revision radical operations (9%) were performed after the initial CWD surgery. These operations were done due to recurrent cholesteatoma and dehiscence of the autogenous obliteration material. An attempt was made to perform the CWD operations with obliteration as a single stage surgery, but revisions were required in 21 patients (30%) with six exhibiting recurrent cholesteatoma (9%).
Currently, over half of our patients do not need regular debridements. The configuration of the cavity tends to change in the long-term. However, the obliteration material is stable and clinically significant cavitation rarely occurs.
The questionnaire complited by the patients
How often did/do you visit your surgeon due to problems related to the operated ear?
1–2 years after the surgery
once/year or seldom
over 6 times/year
5–10 years after the surgery
not at all
once/year or seldom
over 6 times/year
not at all
once per year or seldom
more than 6 times/year
Has the ear discharged after the surgery?
there have been only a few periods of discharge
the ear is discharging frequently
it is discharging continuously
Have you had a revision operation? Yes no
Are you using a hearing aid? Yes no
I use hearing aid(s):
in the operated ear
in the contralateral ear
in both ears
Are you comfortable with using a hearing aid?
due to problems I do not wear it in the operated ear
What kinds of problems did/do occur if you are using a hearing aid?
ear starts to discharge
insertion problems with the ear piece
the hearing level of the ear is too poor to wear an aid
others? What kinds of problems?
How long have you been using a hearing aid?
over 10 years
- Goycoolea MV: Mastoid and tympanomastoid procedures in otitis media: classic mastoidectomy (simple, modified, and radical) and current adaptations; open-cavity, closed-cavity, and intact-bridge tympanomastoidectomy. Otolaryngol Clin North Am. 1999, 32: 513-23. 10.1016/S0030-6665(05)70149-3.View ArticlePubMedGoogle Scholar
- Lee WS, Choi JY, Song MH, Son EJ, Jung SH, Kim SH: Mastoid and epitympanic oblitreration in canal wall up mastoidectomy for prevention of retraction pocket. Otol Neurotol. 2005, 26: 1107-11. 10.1097/01.mao.0000184603.32796.6c.View ArticlePubMedGoogle Scholar
- Della Santina CC, Lee SC: Ceravital reconstruction of canal wall down mastoidectomy: long-term results. Arch Otolaryngol Head Neck Surg. 2006, 132: 617-23. 10.1001/archotol.132.6.617.View ArticlePubMedGoogle Scholar
- Dornhoffer JL: Retrograde mastoidectomy with canal wall reconstruction: a follow-up report. Otol Neurotol. 2004, 25: 653-60. 10.1097/00129492-200409000-00002.View ArticlePubMedGoogle Scholar
- Gantz BJ, Wilkinson EP, Hansen MR: Canal wall reconstruction tympano-mastoidectomy with mastoid obliteration. Laryngoscope. 2005, 115 (10): 1734-40. 10.1097/01.MLG.0000187572.99335.cc.View ArticlePubMedGoogle Scholar
- Magliulo G, D'Amico R, Fusconi M: Reconstruction of old radical cavities and longterm results. J Otolaryngol. 2004, 33 (3): 155-9. 10.2310/7070.2004.00155.View ArticlePubMedGoogle Scholar
- Roberson JB, Mason TP, Stidham KR: Mastoid obliteration: autogenous cranial bone pate reconstruction. Otol Neurotol. 2003, 24 (2): 132-40. 10.1097/00129492-200303000-00002.View ArticlePubMedGoogle Scholar
- Bacciu A, Pasanisi E, Vincenti V, Di Lella F, Bacciu S: Reconstruction of outer attic wall defects using bone pate: Long-term clinical and histological evaluation. Eur Arch Otorhinolaryngol. 2006, 263: 983-7. 10.1007/s00405-006-0098-7.View ArticlePubMedGoogle Scholar
- Ikeda M, Yoshida S, Ikui A, Shigihara S: Canal wall down tympanoplasty with canal reconstruction for middle-ear cholesteatoma: post-operative hearing, cholesteatoma recurrence, and status of re-aeration of reconstructed middle-ear cavity. J Laryngol Otol. 2003, 117: 249-55. 10.1258/00222150360600823.View ArticlePubMedGoogle Scholar
- Montandon P, Benchaou M, Guyot JP: Modified canal wall-up mastoidectomy with mastoid obliteration for severe chronic otitis media. ORL J Otorhinolaryngol Relat Spec. 1995, 57: 198-201.View ArticlePubMedGoogle Scholar
- Kos MI, Cartrillon R, Montandon P, Guyot JP: Anatomic and functional long-term results of canal wall-down mastoidectomy. Ann Otol Rhinol Laryngol. 2004, 113: 872-6.View ArticlePubMedGoogle Scholar
- Leatherman BD, Dornhoffer JL: The use of demineralized bone matrix for mastoid cavity obliteration. Otol Neurotol. 2004, 25: 22-5. 10.1097/00129492-200401000-00005.View ArticlePubMedGoogle Scholar
- Ramsey MJ, Merchant SN, McKenna MJ: Postauricular periosteal-pericranial flap for mastoid obliteration and canal wall down tympanomastoidectomy. Otol Neurotol. 2004, 25: 873-8. 10.1097/00129492-200411000-00004.View ArticlePubMedGoogle Scholar
- Bagot d'Arc M, Daculsi G, Emam N: Biphasic ceramics and fibrin sealant for bone reconstruction in ear surgery. Ann Otol Rhinol Laryngol. 2004, 113: 711-20.View ArticlePubMedGoogle Scholar
- Palva T, Palva A, Karja J: Musculoperiosteal flap in cavity obliteration. Histopathological study seven years postoperatively. Arch Otolaryngol. 1972, 95 (2): 172-7.View ArticlePubMedGoogle Scholar
- Palva T: Surgical control of the mastoid segment in chronic ear disease in 1988. Arch Otorhinolaryngol. 1989, 246 (5): 274-6. 10.1007/BF00463573.View ArticlePubMedGoogle Scholar
- Mehta RP, Harris JP: Mastoid obliteration. Otolaryngol Clin North Am. 2006, 39: 1129-42. 10.1016/j.otc.2006.08.007.View ArticlePubMedGoogle Scholar
- Satar B, Yetiser S, Ozkaptan Y: Evolving acoustic characteristics of the canal wall down cavities due to neo-osteogenesis by periosteal flap. Otol Neurotol. 2002, 23: 845-9. 10.1097/00129492-200211000-00006.View ArticlePubMedGoogle Scholar
- Jang CH: Changes in external ear canal resonance after mastoidectomy: Open cavity mastoid versus obliterated mastoid cavity. Clin Otolaryngol Allied Sci. 2002, 27 (6): 509-11. 10.1046/j.1365-2273.2002.00617.x.View ArticlePubMedGoogle Scholar
- Goode RL, Friedrichs R, Falk S: Effect on hearing thresholds of surgical modification of the external ear. Ann Otol. 1977, 86: 441-50.Google Scholar
- Tolley NS, Ison K, Mirza A: Experimental studies on the acoustic properties of mastoid cavities. J Laryngol Otol. 1992, 106: 597-9. 10.1017/S0022215100120286.View ArticlePubMedGoogle Scholar
- Kahramanyol M: Fascioperiosteal flap and neo-osteogenesis in radical mastoidectomy. Ear Nose Throat J. 1992, 71: 70-7.PubMedGoogle Scholar
- Kahramanyol M, Ozunlu A, Pabuscu Y: Fascioperiosteal flap and neo-osteogenesis in radical mastoidectomy: long-term results. Ear Nose Throat J. 2000, 79 (7): 524-6.PubMedGoogle Scholar
- Humes LE: Modeling and predicting hearing aid outcome. Trends Amplif. 2003, 7 (2): 41-75. 10.1177/108471380300700202.View ArticlePubMedPubMed CentralGoogle Scholar
- Humes LE, Wilson DL: An examination of changes in hearing-aid performance and benefit in the elderly over a 3-year period of hearing-aid use. J Speech Lang Hear Res. 2003, 46 (1): 137-45. 10.1044/1092-4388(2003/011).View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-6815/8/4/prepub
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